L-Tyrosine 1,1-dimethylethyl ester → HCID 178467516, compound

HRID 1825878Notes

Reaction equation

HRID 1825878 reaction equation
C(O[C:4]1[C:8]([O:9][CH2:10][CH3:11])=[N:7][S:6](=[O:13])(=[O:12])[N:5]=1)C.[C:14]([O:18][C:19](=[O:30])[C@H:20]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)[NH2:21])([CH3:17])([CH3:16])[CH3:15]>C(O)C>[C:14]([O:18][C:19](=[O:30])[C@H:20]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)[NH:21][C:4]1[C:8]([O:9][CH2:10][CH3:11])=[N:7][S:6](=[O:12])(=[O:13])[N:5]=1)([CH3:17])([CH3:15])[CH3:16]

Participants

4

Reactant 2

HCID 6950582L-Tyrosine 1,1-dimethylethyl esterHCID 112179953,4-Diethoxy-1,2,5-thiadiazole-1,1-dioxide

Product 1

HCID 178467516HCID 178467516, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3,4-diethyloxy-1,1-dioxo-1,2,5-thiadiazole (400 mg, 1.94 mmol)and L-tyrosine t-butyl ester (1.25 g, 5.2 mmol) in ethanol (25 mL) was stirred at room temperature overnight. Solvent was removed under reduced pressure and the product used in further transformations without further purification (Yield 790 mg).

Workup

  1. customSolvent was removed under reduced pressure
  2. customthe product used in further transformations without further purification (Yield 790 mg)

Sources & evidence

ORD record
ord-343cef9aa5bd4fe9be59bebf3eb14e9f
Source dataset
uspto-grants-2006_05
Patent number
US07049306B2

Reaction notes

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