Acetyl chloride → HCID 69640084, compound

Participants

Reaction Steps

6 ml of N-methylpyrrolidone, 1.11 g (3.4 mmol) of cesium carbonate and 0.27 g (3.4 mmol) of acetyl chloride were added to 0.70 g (1.7 mmol) of methyl 3-{4-amino-2-[3-(2-chloro-4,5-difluorobenzoyl)ureido]phenyl}acrylate and the mixture was stirred at room temperature for 30 minutes. It was then diluted with H2O and extracted with ethyl acetate. The organic phase was washed with H2O, dried and concentrated. 0.65 g (85%) of the desired product was obtained.

Provenance & Evidence