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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1825980Generated: October 31, 2026

Ethyl indole-2-carboxylate → 5-fluoro-1-methyl-1H-indole-3-carbaldehyde

https://huagongshe.com/reaction/1825980

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl indole-2-carboxylateHCID 73125—
Reactant5-fluoro-1H-indole-3-carbaldehydeHCID 259089—
Product5-fluoro-1-methyl-1H-indole-3-carbaldehydeHCID 138200950%

Reaction Steps

According to the procedure of Preparation 9 (a), except substituting 5-fluoro-1H-indole-3-carboxaldehyde (0.3 g, 1.8 mmole) for the ethyl indole-2-carboxylate, the title compound (0.16 g, 50%) was prepared as a viscous oil: MS (ES) m/e 178 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07049310B2
Source datasetuspto-grants-2006_05
ORD IDord-410108e90b2e49f3bdf06d4d7f76501f
Source noteuspto-grants-2006_05