Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1825985Generated: October 30, 2026

1,3-dimethyl-1H-indole-2-carbaldehyde → 1-Ethyl-5-fluoro-3-(methylaminomethyl)-1H-indole

https://huagongshe.com/reaction/1825985

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-dimethyl-1H-indole-2-carbaldehydeHCID 2771468—
Reactant1-ethyl-5-fluoro-1H-indole-3-carbaldehydeHCID 22138998—
ReactantMethyl 2-((5-bromopyridin-2-yl)amino)acetateHCID 22139049—
Product1-Ethyl-5-fluoro-3-(methylaminomethyl)-1H-indoleHCID 2213909650%

Reaction Steps

According to the procedure of Preparation 11 (c), except substituting 1-ethyl-5-fluoro-1H-indole-3-carboxaldehyde (0.2 g,1.9 mmole) for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (0.1 g, 50%) was prepared as a viscous oil: MS (ES) m/e 207 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07049310B2
Source datasetuspto-grants-2006_05
ORD IDord-fe069391ddc647c59b9c5bea99caa8f8
Source noteuspto-grants-2006_05