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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1826021Generated: October 29, 2026

1,3-dimethyl-1H-indole-2-carbaldehyde → 7-fluoro-3-(methylaminomethyl)-1H-indole

https://huagongshe.com/reaction/1826021

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-dimethyl-1H-indole-2-carbaldehydeHCID 2771468—
Reactant7-Fluoro-1H-indole-3-carbaldehydeHCID 22139120—
Product7-fluoro-3-(methylaminomethyl)-1H-indoleHCID 2213905990%

Reaction Steps

According to the procedure of Preparation 13 (c),except substituting 7-fluoro-1H-indole-3-carboxaldehyde (0.5 g, 3.1 mmole) for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (0.5 g, 90%) was prepared as a viscous oil: MS (ES) m/e 179 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07049310B2
Source datasetuspto-grants-2006_05
ORD IDord-163be56b31694636bc837a32100ddbfd
Source noteuspto-grants-2006_05