1,3-dimethyl-1H-indole-2-carbaldehyde → [(4-fluoro-1H-indol-3-yl)methyl](methyl)amine

HRID 1826022Notes

Reaction equation

HRID 1826022 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([CH:11]=O)=[CH:5][NH:6]2.[CH3:13][N:14]1C2C(=CC=CC=2)C(C)=C1C=O>>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([CH2:11][NH:14][CH3:13])=[CH:5][NH:6]2

Participants

3

Reactant 2

HCID 27714681,3-dimethyl-1H-indole-2-carbaldehydeHCID 221390064-Fluoro-1H-indole-3-carbaldehyde

Product 1

HCID 22139121[(4-fluoro-1H-indol-3-yl)methyl](methyl)amine

Procedure

According to the procedure of Preparation 13 (c),except substituting 4-fluoro-1H-indole-3-carboxaldehyde for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound was prepared as a viscous oil: MS (ES) m/e 179 (M+H)+.

Workup

  1. customAccording to the procedure of Preparation 13

Sources & evidence

ORD record
ord-54d4344c508d4f498e2bac10cfad1a0e
Source dataset
uspto-grants-2006_05
Patent number
US07049310B2

Reaction notes

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