Sodium Hydroxide → HCID 12017968, compound

HRID 1826070Notes

Reaction equation

HRID 1826070 reaction equation
[CH3:1][O:2][CH:3]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([NH:18][C:19](=[O:31])[CH2:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=2)[CH:11]=1)[C:4]([O:6]CC)=[O:5].[OH-].[Na+]>CO>[CH3:1][O:2][CH:3]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([NH:18][C:19](=[O:31])[CH2:20][C:21]2[CH:22]=[CH:23][C:24]([C:27]([F:29])([F:30])[F:28])=[CH:25][CH:26]=2)[CH:11]=1)[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12017937HCID 12017937, compound

Product 1

HCID 12017968HCID 12017968, compoundYield 93.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 2-methoxy-3-[4-methoxy-3-[2-[4-(trifluoromethyl)phenyl]acetylamino]phenyl]propanoate (442 mg, 0.986 mmol), methanol (9 mL) and 1 mol/L aqueous solution of sodium hydroxide (5 mL) were mixed. After stirring for 5 hours at room temperature, the reaction mixture was concentrated under reduced pressure. The residue was dissolved in water, washed with ether, and then made acidic with diluted hydrochloric acid. The precipitates produced were filtered and dried to afford 379 mg (93%) of the title compound as pale yellow crystals.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. dissolutionThe residue was dissolved in water
  3. washwashed with ether
  4. customThe precipitates produced
  5. filtrationwere filtered
  6. customdried

Sources & evidence

ORD record
ord-23f444bfe1a34dee929a4ec9bd559de0
Source dataset
uspto-grants-2006_05
Patent number
US07049342B2

Reaction notes

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