Acetic Anhydride → HCID 22141583, compound

Participants

Reaction Steps

0.10 g (0.36 mmol) of 6-(diphenylphosphino)-2-aminopyridine from example 14.3.1 was dissolved in 2.0 ml of dichloromethane and admixed with 0.05 ml (0.04 g, 0.40 mmol) of triethylamine and a spatula-tip of DMAP. After 0.04 ml (0.04 g, 0.40 mmol) of acetic anhydride had been added, the mixture was stirred at room temperature for 2 h and then the solvent was removed under reduced pressure. The residue was purified by column chromatography with cyclohexane/ethyl acetate (1:1). 0.074 g (0.23 mmol, 63.9%) of 6-(diphenylphosphino)-2-acetylaminopyridine was obtained as a beige-colored solid.

Provenance & Evidence