反应详情

温度

80 °C

1.0 g (5.05 mmol) of 1,3-dichloroisoquinoline from example 16.2 was dissolved in 20 ml of dry toluene, admixed with 0.68 g (6.06 mmol) of potassium tert-butoxide and stirred at 80° C. for 3 h. After the mixture had been cooled, it was filtered together with 50 ml of dichloromethane through a short silica gel column (1×5 cm) and the solvent was removed under reduced pressure. 1.06 g (4.50 mmol, 89.1%) of 1-t-butoxy-3-chloroisoquinoline were obtained.

1. temperatureAfter the mixture had been cooled
2. filtrationit was filtered together with 50 ml of dichloromethane through a short silica gel column (1×5 cm)
3. customthe solvent was removed under reduced pressure