HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1826260Generated: November 1, 2026
Phosphorus oxychloride → 4-Chloro-7-fluoro-5-tetrahydropyran-4-yloxyquinazoline
https://huagongshe.com/reaction/1826260
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 7-Fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4(3H)-one | HCID 135742095 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 4-Chloro-7-fluoro-5-tetrahydropyran-4-yloxyquinazoline | HCID 22140799 | — |
Reaction Steps
A mixture of 7-fluoro-5-tetrahydropyran-4-yloxy-3,4-dihydroquinazolin-4-one (1 g), phosphoryl chloride (4 ml), diisopropylethylamine (1.5 ml) and 1,2-dichloroethane (15 ml) was stirred and heated to 80° C. for 3 hours. The mixture was evaporated to give 4-chloro-7-fluoro-5-tetrahydropyran-4-yloxyquinazoline which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07049438B2 |
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| Source dataset | uspto-grants-2006_05 |
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| ORD ID | ord-da63c26bbb4f43eaafece529c18da3eb |
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| Source note | uspto-grants-2006_05 |
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