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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 18263Generated: October 25, 2026

1,3-dimethyl-1H-indole-2-carbaldehyde → 6-fluoro-1-methyl-3-(methylaminomethyl)-1H-indole

https://huagongshe.com/reaction/18263

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-dimethyl-1H-indole-2-carbaldehydeHCID 2771468—
Reactant6-Fluoro-1-methyl-1H-indole-3-carbaldehydeHCID 6498197—
ReactantMethyl 2-((5-bromopyridin-2-yl)amino)acetateHCID 22139049—
Product6-fluoro-1-methyl-3-(methylaminomethyl)-1H-indoleHCID 2213915835%

Reaction Steps

According to the procedure of Preparation 11 (c), except substituting 6-fluoro-1-methyl-1H-indole-3-carboxaldehyde (0.3 g, 1.69 mmole) for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (0.11 g, 35%) was prepared as a viscous oil: MS (ES) m/e 193 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07741339B2
Source datasetuspto-grants-2010_06
ORD IDord-00e4e9be91044d3da0f4b338f7404e08
Source noteuspto-grants-2010_06