HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Tetrachloride → 4-Chloro-5-fluoroquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Tetrachloride | HCID 5943 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 5-Fluoroquinazolin-4-ol | HCID 135495930 | — |
| Product | 4-Chloro-5-fluoroquinazoline | HCID 11974445 | — |
Reaction Steps
Thus, 5-fluoro-3,4-dihydroquinazolin-4-one (2 g) was reacted with triphenylphosphine and carbon tetrachloride to give 5-fluoro-4-chloroquinazoline (1.34 g); NMR Spectrum: (CDCl3) 7.4–7.5 (m, 1H), 7.9–8.0 (m, 2H), 9.1 (s, 1H); and
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07049438B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-f221d8c248524c2f9c4c4ab15d6ed158 |
| Source note | uspto-grants-2006_05 |