Aluminium lithium hydride → HCID 178444661, compound

Participants

Reaction Steps

To a solution of 3-hexyl-6-methyl-6-[3-(1H-1,2,3-triazol-4-yl)phenyl]-3-azabicyclo[3.1.0]hexan-2-one (Preparation 40, 2.88 mmol) in tetrahydrofuran (25 ml) at 0° C. was added lithium aluminium hydride (5.8 ml, 5.76 mmol, 1.0M in THF) dropwise over a few minutes. The mixture was stirred at room temperature for 2 hours and then quenched by the cautious addition of 2N sodium hydroxide (3 ml) at 0° C. Ethyl acetate (15 ml) was then added and the mixture was stirred rapidly for 30 minutes and then filtered through celite washing with ethyl acetate. The solvent was evaporated in vacuo and the crude residue was purified by silica column chromatography eluting with hexane:ethyl acetate (1:1) then ethyl acetate:methanol:ammonia solution (0.880) (95:5:1) to afford the title compound (301 mg, 32% over 2 steps) as a colourless oil.

Provenance & Evidence