Dichloromethane → Ammonia

Participants

Reaction Steps

To a solution of 2-[3-hexyl-6-methyl-3-azabicyclo[3.1.0]hex-6-yl]phenylamine (Preparation 140, 30 mg, 0.11 mmol) in pyridine (1.0 ml) under a nitrogen atmosphere at room temperature was added dropwise methane sulfonyl chloride (13 μl, 0.16 mmol), and the reaction mixture was stirred at room temperature for 2 d. Ice (2 g) and dichloromethane (5 ml) were added, the layers were separated and the aqueous layer was further extracted with dichloromethane (5 ml). The combined extracts were dried (Na2SO4), filtered and concentrated in vacuo. This was purified by chromatography using silica gel (1.5 g) eluting with dichloromethane:ethanol:0.880 ammonia (200:8:1) to afford the title compound as a very pale yellow oil (5.2 mg, 14%).

Provenance & Evidence