Methanesulfonyl chloride → HCID 22141210, compound

HRID 1826395Notes

Reaction equation

HRID 1826395 reaction equation
[CH3:1][C:2]1([C:17]2[CH:18]=[C:19]([NH2:23])[CH:20]=[CH:21][CH:22]=2)[CH:7]2[CH:3]1[CH2:4][N:5]([CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:6]2.[CH3:24][S:25]([Cl:28])(=[O:27])=[O:26]>CC(C)=O>[ClH:28].[CH3:1][C:2]1([C:17]2[CH:18]=[C:19]([NH:23][S:25]([CH3:24])(=[O:27])=[O:26])[CH:20]=[CH:21][CH:22]=2)[CH:3]2[CH:7]1[CH2:6][N:5]([CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:4]2

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 11266768HCID 11266768, compound

Product 1

HCID 22141210HCID 22141210, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 3-[6-methyl-3-(3-phenylpropyl)-3-azabicyclo[3.1.0]hex-6-yl]phenylamine (Preparation 8, 1.00 g, 3.26 mmol) in acetone (5 ml) at 0° C. was added methanesulfonyl chloride (0.28 ml, 3.58 mmol) and the reaction mixture was stirred at room temperature overnight. The resulting precipitate was collected by filtration to afford the title compound as a white crystalline solid (1.19 g, 87%).

Workup

  1. filtrationThe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-e9faab362f51402bb0929528c9f67132
Source dataset
uspto-grants-2006_05
Patent number
US07049444B2

Reaction notes

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