p-Toluenesulfonic acid → HCID 22141161, compound

Participants

Reaction Conditions

Reaction Steps

A solution of N-(3-{6-methyl-3-(3-phenylpropyl)-3-azabicyclo[3.1.0]hex-6-yl}phenyl)methanesulfonamide (Example 1, 25.00 g, 65 mmol) in ethyl acetate (250 ml) was heated under reflux. To the solution was added para-toluenesulfonic acid (12.36 g, 72 mmol) and the reaction mixture was heated under reflux for 60 min before cooling to 10° C. over a 2 h period. The resulting precipitate was collected by filtration to afford the title compound as a white solid (35.46 g, 95%).

Provenance & Evidence