Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 3-(hexylcarbamoyl)prop-2-enoic Acid | HCID 2731432 | — |
| Solvent | Acetic Anhydride | HCID 7918 | — |
| Product | 1-Hexylpyrrole-2,5-dione | HCID 464134 | — |
Reaction Steps
4-(Hexylamino)-4-oxo-2-butenoic acid (Preparation 54, 75.8 g, 0.38 mol) was partially dissolved in acetic anhydride (1.5 l) and sodium acetate (125.6 g, 0.19 mol) was added in one portion. The reaction mixture was gradually heated to 110° C. for 4 h. Acetic anhydride was removed in vacuo and the title compound was obtained by vacuum distillation of the crude residue to give a colourless oil (49.8 g, 72%) which partially crystallised upon standing.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07049444B2 |
|---|
| Source dataset | uspto-grants-2006_05 |
|---|
| ORD ID | ord-0ffb830baa06494dbf71fcf50b481245 |
|---|
| Source note | uspto-grants-2006_05 |
|---|
