HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-3-Phenylpropane-1,2-diamine → 2-(2 (S)-Amino-3-phenyl-propylamino)-3-methyl-5-nitro-6-pyridin-4-yl-3H-pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-3-Phenylpropane-1,2-diamine | HCID 12699301 | — |
| Reactant | 3-Methyl-2-methylsulfanyl-5-nitro-6-pyridin-4-yl-3H-pyrimidin-4-one | HCID 22139609 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(2 (S)-Amino-3-phenyl-propylamino)-3-methyl-5-nitro-6-pyridin-4-yl-3H-pyrimidin-4-one | HCID 58633721 | — |
Reaction Steps
A solution of 3-methyl-2-methylsulfanyl-5-nitro-6-pyridin-4-yl-3H-pyrimidin-4-one (0.31 mmol) in dimethylformamide (DMF) was added 3-phenyl-propane-1,2 (S)-diamine (0.92 mmol) and stirred overnight at room temperature. The DMF was removed under vacuum, and the product purified on silica as a mixture of isomers. M+1=381.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07049318B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-af276e5afedb49d3bcd7ba98c8d1089f |
| Source note | uspto-grants-2006_05 |