Diethyl Ether → HCID 178481604, compound

HRID 1826517Notes

Reaction equation

HRID 1826517 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[CH:6]=[C:5]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[N:4]=[C:3]1SC.[N+:17]([O-])([O-:19])=[O:18].[K+].C([O:24]CC)C>S(=O)(=O)(O)O>[OH:24][C:3]1[N:2]([CH3:1])[C:7](=[O:8])[C:6]([N+:17]([O-:19])=[O:18])=[C:5]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[N:4]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 24434Potassium NitrateHCID 155215183-methyl-2-methylsulfanyl-6-pyridin-4-yl-3H-pyrimidin-4-one

Product 1

HCID 178481604HCID 178481604, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Conditions

Temperature
70 °C

Procedure

To a stirring solution of 3-methyl-2-methylsulfanyl-6-pyridin-4-yl-3H-pyrimidin-4-one (15.5 mmol) in 40 mL sulfuric acid was added potassium nitrate (62.1 mmol). The reaction was heated to 70° C. for 3 h. Reaction was then added to stirring diethyl ether (400 mL), and precipitate collected by filtration. The precipitate was suspended in water and the pH was adjusted to 3 using sodium hydroxide. The solid was collected by filtration. M+1=249.

Workup

  1. customReaction
  2. additionwas then added
  3. filtrationcollected by filtration
  4. filtrationThe solid was collected by filtration

Sources & evidence

ORD record
ord-0d9e616a7c984ad496bfa4dee869fc4e
Source dataset
uspto-grants-2006_05
Patent number
US07049318B2

Reaction notes

Loading…