HCID 178418361, compound → HCID 178481603, compound

HRID 1826518Notes

Reaction equation

HRID 1826518 reaction equation
[OH:1][C:2]1[N:7]([CH3:8])[C:6](=[O:9])[C:5]([N+:10]([O-])=O)=[C:4]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[N:3]=1.[H][H]>CO.[OH-].[Na+].[Pd]>[NH2:10][C:5]1[C:6](=[O:9])[N:7]([CH3:8])[C:2]([OH:1])=[N:3][C:4]=1[C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1

Participants

6

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178481604HCID 178481604, compound

Product 1

HCID 178481603HCID 178481603, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

To a solution of 2-hydroxy-3-methyl-5-nitro-6-pyridin-4-yl-3H-pyrimidin-4-one (22.6 mmol) in 200 mL methanol and 75 mL 1N sodium hydroxide was added 50 mg Pd/C and stirred overnight under a balloon filled with hydrogen. The solvents were removed under vacuum. The solids were suspended in water and acidified to pH 5 with SN HCl. The solid was collected by filtration. M+1=219.

Workup

  1. customThe solvents were removed under vacuum
  2. filtrationThe solid was collected by filtration

Sources & evidence

ORD record
ord-13b248c7849b425eb622d8add81b8ab4
Source dataset
uspto-grants-2006_05
Patent number
US07049318B2

Reaction notes

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