HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1826519Generated: November 1, 2026
Phosphorus oxychloride → 5-Amino-2-chloro-3-methyl-6-(pyridin-4-yl)pyrimidin-4(3H)-one
https://huagongshe.com/reaction/1826519
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178481603 | HCID 178481603 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Amino-2-chloro-3-methyl-6-(pyridin-4-yl)pyrimidin-4(3H)-one | HCID 22139587 | — |
Reaction Steps
5-Amino-2-hydroxy-3-methyl-6-pyridin-4-yl-3H-pyrimidin-4-one (0.46 mmol) was suspended in phosphorousoxychloride (230 mmol) at 0° C. and 2 mL ethanol was added. The reaction was heated to 100° C. overnight. The solvent was removed under vacuum. The solid was suspended in methylene chloride and collected by filtration. M+1=237.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07049318B2 |
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| Source dataset | uspto-grants-2006_05 |
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| ORD ID | ord-70a42aa7fbcf4a4e87185ca5487f1f6a |
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| Source note | uspto-grants-2006_05 |
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