HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → N-[2-(2(S)-Amino-3-phenyl-propylamino)-1-methyl-6-oxo-4-pyridin-4-yl-1,6-dihydro-pyrimidin-5-yl]-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (2S)-3-Phenylpropane-1,2-diamine | HCID 12699301 | — |
| Reactant | N-(2-Chloro-1-methyl-6-oxo-4-pyridin-4-yl-1,6-dihydro-pyrimidin-5-yl)-benzamide | HCID 22139582 | — |
| Product | N-[2-(2(S)-Amino-3-phenyl-propylamino)-1-methyl-6-oxo-4-pyridin-4-yl-1,6-dihydro-pyrimidin-5-yl]-benzamide | HCID 23574695 | — |
Reaction Steps
N-(2-Chloro-1-methyl-6-oxo-4-pyridin-4-yl-1,6-dihydro-pyrimidin-5-yl)-benzamide (0.07 mmol) was stirred as a solution with 3-phenyl-propane-1,2(S)-diamine (0.15 mmol) and diisopropylethylamine (0.1 mmol) at 0° C. for 2 h. The material was purified on reverse phase HPLC. M+1=455.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07049318B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-e08173cc7eff44f88ea9635e78a622e6 |
| Source note | uspto-grants-2006_05 |