HCID 11751674, compound → HCID 23574678, compound

HRID 1826525Notes

Reaction equation

[NH2:1][C@@H:2]([CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:3][NH:4][C:5]1[N:6]([CH3:28])[C:7](=[O:27])[C:8]([N:17]2[CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:18]2=[O:26])=[C:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[N:10]=1.[2H]C([2H])([2H])C#N.[2H]O[2H]>>[NH2:1][C@@H:2]([CH2:29][CH:30]1[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1)[CH2:3][NH:4][C:5]1[N:6]([CH3:28])[C:7](=[O:27])[C:8]([N:17]2[CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:18]2=[O:26])=[C:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[N:10]=1

Participants

Reactant 2

HCID 11751674HCID 11751674, compound

HCID 131725767CD3CN D2O

Product 1

HCID 23574678HCID 23574678, compound

Procedure

The compound was prepared similar to that of 2-[2-(2 (S)-Amino-3-phenyl-propylamino)-1-methyl-6-oxo-4-pyridin-4-yl-1,6-dihydro-pyrimidin-5-yl]-2,3-dihydro-isoindol-1-one (Example 12). M+1=473. NMR H1 (CD3CN/D2O) m (2H, 0.85 ppm), m (3H, 1.15 ppm), m (8H, 1.4–1.7 ppm), s (3H, 3.4 ppm), m (2H, 3.5 ppm), m (1H, 3.7 ppm), t (1H, 4.45 ppm), dd (1H, 4.95 ppm), t (1H, 7.55 ppm), t (1H, 7.6 ppm), m (2H, 7.7 ppm), d (2H, 8.1 ppm), d (2H, 8.7 ppm).

Sources & evidence

ORD record: ord-54aa3e674f5e426b957e57a64d442424
Source dataset: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07049318B2

Reaction notes

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