HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl morpholine oxide → Methyl 2-bromo-6-formylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl morpholine oxide | HCID 82029 | — |
| Reactant | Methyl 2-bromo-6-(bromomethyl)benzoate | HCID 23574705 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Methyl 2-bromo-6-formylbenzoate | HCID 23574706 | — |
Reaction Steps
A suspension of 2-bromo-6-bromomethyl-benzoic acid methyl ester (21.8 mmol), N-methylmorpholine N-oxide (43.6 mmol) and 35 g powdered 4 Å molecular sieves in 350 mL acetonitrile was stirred for 1.5 h at room temperature. The reaction was filtered through a bed of silica, and the filtrate was purified on silica.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07049318B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-da56197f29e24d5d9acfd7a526560f7d |
| Source note | uspto-grants-2006_05 |