反应详情

温度

150 °C

A mixture of 5-amino-2-(2-amino-3-phenyl-propylamino)-3-methyl-6-pyridin-4-yl-3H-pyrimidin-4-one (100 mg, 0.22 mmol), and isobenzofuran-1,3-dione (50 mg, 0.33 mmol) in DMF (0.5 mL) was heated under microwave irradiation (150° C.) for 10 min. The cooled mixture was diluted with CH2Cl2 (2 mL) followed by the addition of TFA (1 nL). After being stirred at room temperature for 6 h, the mixture was concentrated, partitioned between NaHCO3 (aq) and CH2Cl2. The organic residue was purified on silica (1–10% MeOH in CH2Cl2) to afford the desired product as a light yellow solid. M+1 481.

1. concentrationthe mixture was concentrated
2. custompartitioned between NaHCO3 (aq) and CH2Cl2
3. customThe organic residue was purified on silica (1–10% MeOH in CH2Cl2)