Isobutyloxirane → HCID 22139594, compound

Participants

Reaction Conditions

Reaction Steps

In a 100 mL RBF with stirrer bar was charged 3-nitro-2-pyridin-4-yl-6,7,8,9-tetrahydro-pyrimido[1,2-a]pyrimidin-4-one (1.0 g) and 2-isobutyl-oxirane (0.7 g) in DMF (7 mL) under nitrogen. A solution of LiHMDS (1N in THF, 7 mL) was added to the mixture, resulting a red solution. Affter being heated at 80° C. overnight the mixture was cooled to room temperature and was partitioned between CH2Cl2 and NH4Cl (aq.). The organic phase was further washed with H2O, dried with Na2SO4, concentrated, and eluted on silica gel (0–7% 2N NH3-MeOH in DCM) to afford the product that was used directly in the next step. M+1 374.

Provenance & Evidence