Ammonia → HCID 22133763, compound

HRID 1826538Notes

Reaction equation

HRID 1826538 reaction equation
Cl[C:2]1[N:10]=[C:9]([I:11])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=1)[N:6]2[CH3:12].[NH3:20]>>[F:19][C:15]1[CH:14]=[C:13]([C:5]2[N:6]([CH3:12])[C:7]3[C:3]([N:4]=2)=[C:2]([NH2:20])[N:10]=[C:9]([I:11])[N:8]=3)[CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 99522656-chloro-8-(3-fluorophenyl)-2-iodo-9-methyl-9H-purine

Product 1

HCID 22133763HCID 22133763, compound

Procedure

6-Chloro-8-(3-fluorophenyl)-2-iodo-9-methyl-9H-purine (200 mg) was reacted with an ammonia-saturated methanol at 70° C. for 30 minutes in a sealed tube. The reaction mixture was evaporated and then filtered to give 138 mg of 8-(3-fluorophenyl)-2-iodo-9-methyl-9H-6-purinamine.

Workup

  1. customThe reaction mixture was evaporated
  2. filtrationfiltered

Sources & evidence

ORD record
ord-8318b93aad7e4d95a706ec419266e7db
Source dataset
uspto-grants-2006_05
Patent number
USRE039112E1

Reaction notes

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