HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → (2-Propyl-thiazol-5-yl)methyl 4-(5-undecyl-pyrimidin-2-yl)phenyl ether
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Reactant | (2-Propyl-1,3-thiazol-5-yl)methanol | HCID 22134228 | — |
| Reactant | 4-(5-Undecylpyrimidin-2-yl)phenol | HCID 135619682 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (2-Propyl-thiazol-5-yl)methyl 4-(5-undecyl-pyrimidin-2-yl)phenyl ether | HCID 22134209 | — |
Reaction Steps
A fully reacted mixture of equimolar amounts of diethyl azodicarboxylate and triphenylphosphine in THF is admixed with equimolar amounts of 4-(5-undecyl-pyrimidin-2-yl)phenol and 2-propylthiazol-5-yl-methanol (prepared by LiAlH4 reduction of methyl 2-propylthiazole-5-carboxylate). The mixture is stirred for 24 h at room temperature and then evaporated to dryness under reduced pressure. Purification by chromatography (silica gel, dichloromethane) and recrystallization affords the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07052742B1 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-1c2d38b5afb54b469b294cf122cf89c2 |
| Source note | uspto-grants-2006_05 |