Methanol → 2-Methanesulfinyl-pyrido[2,3-d]pyrimidin-7-ylamine

Participants

Reaction Steps

A suspension of 10.63 g (55.3 mmol) of 2-methylsulfanyl-pyrido[2,3-d]pyrimidin-7-ylamine (Example 7) in 300 mL of dichloromethane and 300 mL of methanol is treated with 18.06 g (69.1 mmol) of (±)-trans-2-(phenylsulfonyl)-3-phenyloxaziridine and stirred overnight. The suspension is filtered to remove a small amount of solid, concentrated to approximately 25 mL, and diluted with ethyl acetate. The solid is collected by filtration to give 9.27 g (80.5%) of the product, mp 180° C. (dec).

Provenance & Evidence