Cyclopentanone → HCID 69592702, compound

HRID 1826604Notes

Reaction equation

HRID 1826604 reaction equation
[C:1]([CH:8]([NH2:15])[CH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[C:16]1(=O)[CH2:20][CH2:19][CH2:18][CH2:17]1>>[C:1]([CH:8]([NH2:15])[CH:9]1[CH2:10][CH2:11][N:12]([CH:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[CH2:13][CH2:14]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Participants

3

Reactant 2

HCID 8452CyclopentanoneHCID 22257597HCID 22257597, compound

Product 1

HCID 69592702HCID 69592702, compoundYield 77.4%

Procedure

Using Alkylation Method B, 4-(Boc-aminomethyl)piperidine (15 g, 70 mmol) and cyclopentanone (36 g, 450 mmol) afforded 15.3 g (77%) of the title compound.

Sources & evidence

ORD record
ord-e975177fdb5d47bb90e66b875dc5615c
Source dataset
uspto-grants-2006_05
Patent number
US07053078B2

Reaction notes

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