反应详情

To a solution of 4-(2-benzyloxybenzyl)benzyl alcohol (0.67 g) in dichloromethane (30 mL) was added thionyl chloride (0.48 mL), and the mixture was heated under reflux for 1 hour. The reaction mixture was concentrated under reduced pressure, water was added to the residue, and the resulting mixture was extracted with diethyl ether. The organic layer was washed with brine and dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure to give 4-(2-benzyloxybenzyl)benzyl chloride (0.68 g).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 1 hour
3. concentrationThe reaction mixture was concentrated under reduced pressure, water
4. additionwas added to the residue
5. extractionthe resulting mixture was extracted with diethyl ether
6. washThe organic layer was washed with brine
7. dry with materialdried over anhydrous sodium sulfate
8. customthe solvent was removed under reduced pressure