Tetrahydrofuran → HCID 86760089, compound

Participants

Reaction Steps

A mixture of 3.37 g (10.0 millimoles) of (±)-7,8-dihydro-8-methyl-5-(3-methyl-4-nitro-phenyl)-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepine, 1.95 g (12.0 millimoles) of 1,1′-carbonyl-diimidazole and 75 ml of anhydrous tetrahydrofurane is stirred under boiling for 20 hours. The reaction mixture is cooled with icecold water. The precipitated product is filtered and washed with 50 ml of diethyl ether. Thus 3.55 g of the desired product are obtained, yield 82%, mp.: 223–226° C.

Provenance & Evidence