1,4-Dioxane → HCID 22135222, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3.37 g (10.0 millimoles) of 8-methyl-5-(4-nitro-3-methyl-phenyl)-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepine, 1.66 g (10.5 millimoles) of selen(IV)oxide and 100 ml of dioxane is stirred on an oil-bath at 80° C. for 3 hours. The solution is filtered on a hot coal-bed washed with 50 ml of hot dioxane and evaporated in vacuo. The crude product obtained is treated with 20 ml of acetonitrile. Thus 2.42 g of the desired compound are obtained, yield 69%, mp.: 188–191° C.

Provenance & Evidence