Water → HCID 86760094, compound

HRID 1826698Notes

Reaction equation

HRID 1826698 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:11]2[C:17]3[CH:18]=[C:19]4[O:24][CH2:23][O:22][C:20]4=[CH:21][C:16]=3[CH2:15][CH:14]([C:25]([NH2:27])=[O:26])[NH:13][N:12]=2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].O.[C:29](OC(=O)C)(=[O:31])[CH3:30]>>[C:29]([N:13]1[CH:14]([C:25]([NH2:27])=[O:26])[CH2:15][C:16]2[CH:21]=[C:20]3[O:22][CH2:23][O:24][C:19]3=[CH:18][C:17]=2[C:11]([C:4]2[CH:5]=[CH:6][C:7]([N+:8]([O-:10])=[O:9])=[C:2]([CH3:1])[CH:3]=2)=[N:12]1)(=[O:31])[CH3:30]

Participants

4

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 86760093HCID 86760093, compound

Product 1

HCID 86760094HCID 86760094, compoundYield 81%

Procedure

3.68 g (10.0 millimoles) of (±)-7,8-dihydro-5-(3-methyl-4-nitro-phenyl)-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-8-carboxylic acid-amide are suspended in 30 ml of acetic anhydride and stirred at room temperature for 48 hours. The reaction mixture is cooled with icecold water, the precipitated product is filtered and washed with 20 ml of diethyl ether. Thus 3.32 g of the desired compound are obtained, yield 81%, mp.: 157–161° C.

Workup

  1. filtrationthe precipitated product is filtered
  2. washwashed with 20 ml of diethyl ether

Sources & evidence

ORD record
ord-47a35488ca6546ca95290c52befab97d
Source dataset
uspto-grants-2006_05
Patent number
US07053082B1

Reaction notes

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