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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1826761Generated: November 3, 2026

Acetic Acid → HCID 69584053, compound

https://huagongshe.com/reaction/1826761

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AcidHCID 176—
ReactantPyrrolidineHCID 31268—
Reactant3-(2-formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)propionic acidHCID 10609002—
Reactant4-(Piperidin-4-yl)indolin-2-oneHCID 22135396—
SolventEthanolHCID 702—
ProductHCID 69584053HCID 69584053—

Reaction Steps

A mixture of 4-piperidin-4-yl-1,3-dihydroindol-2-one (45 mg, 0.2 mmol), 3-(2-formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propionic acid (57 mg, 0.23 mmol) and pyrrolidine (0.3 mL) in ethanol (0.5 mL) was heated to reflux for 2 hours. Acetic acid (0.05 mL) was added to the reaction and heating was continued for another 10 minutes. The reaction was cooled and the precipitate which formed was collected by vacuum filtration, washed with ethanol and dried to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07053086B2
Source datasetuspto-grants-2006_05
ORD IDord-13bc7a50860f4f349447a94290ec4c12
Source noteuspto-grants-2006_05