3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrole-2-carbaldehyde → 4-(6-Aminopyridin-3-yl)-3-[3,5-dimethyl-4-(4-methylpiperazin-1-ylcarbonyl)-1H-pyrrol-2-ylmethylene]-1,3-dihydroindol-2-one

HRID 1826792Notes

Reaction equation

HRID 1826792 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][CH:14]=[C:13]3[C:9]=2[CH2:10][C:11](=[O:17])[NH:12]3)=[CH:4][CH:3]=1.[CH3:18][C:19]1[C:23]([C:24]([N:26]2[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28][CH2:27]2)=[O:25])=[C:22]([CH3:33])[NH:21][C:20]=1[CH:34]=O>>[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][CH:14]=[C:13]3[C:9]=2[C:10](=[CH:34][C:20]2[NH:21][C:22]([CH3:33])=[C:23]([C:24]([N:26]4[CH2:27][CH2:28][N:29]([CH3:32])[CH2:30][CH2:31]4)=[O:25])[C:19]=2[CH3:18])[C:11](=[O:17])[NH:12]3)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 121115823,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrole-2-carbaldehydeHCID 221354324-(6-Aminopyridin-3-yl)-1,3-dihydroindol-2-one

Product 1

HCID 695841254-(6-Aminopyridin-3-yl)-3-[3,5-dimethyl-4-(4-methylpiperazin-1-ylcarbonyl)-1H-pyrrol-2-ylmethylene]-1,3-dihydroindol-2-one

Procedure

4-(6-Aminopyridin-3-yl)-1,3-dihydroindol-2-one (56 mg, 0.25 mmol) was condensed with 3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrole-2-carbaldehyde (69 mg, 0.275 mmol) to give the title compound.

Sources & evidence

ORD record
ord-77604d18d7714dcb9a28a5fa763cb83b
Source dataset
uspto-grants-2006_05
Patent number
US07053086B2

Reaction notes

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