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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 18268Generated: October 25, 2026

Ethyl indole-2-carboxylate → 1-ethyl-5-fluoro-1H-indole-3-carbaldehyde

https://huagongshe.com/reaction/18268

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl indole-2-carboxylateHCID 73125—
Reactant5-fluoro-1H-indole-3-carbaldehydeHCID 259089—
Product1-ethyl-5-fluoro-1H-indole-3-carbaldehydeHCID 2213899857%

Reaction Steps

According to the procedure of Preparation 9 (a), except substituting 5-fluoro-1H-indole-3-carboxaldehyde (0.41 g, 2.5 mmole) for the ethylindole-2-carboxylate, the title compound (0.20 g, 57%) was prepared as a viscous oil: MS (ES) m/e 191 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07741339B2
Source datasetuspto-grants-2010_06
ORD IDord-22b7264a9a4a4c3cb7ea6fc693fa027d
Source noteuspto-grants-2010_06