Potassium Carbonate → Quinolin-7-yl-[6-(4-trifluoromethyl-piperidin-1-yl)-pyrimidin-4-yl]-amine

HRID 1826823노트

반응식

HRID 1826823 반응식
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:18]=[C:17]3[C:12]([CH:13]=[CH:14][CH:15]=[N:16]3)=[CH:11][CH:10]=2)[CH:3]=1.[F:19][C:20]([F:28])([F:27])[CH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[N:16]1[C:17]2[C:12](=[CH:11][CH:10]=[C:9]([NH:8][C:4]3[CH:3]=[C:2]([N:24]4[CH2:25][CH2:26][CH:21]([C:20]([F:28])([F:27])[F:19])[CH2:22][CH2:23]4)[N:7]=[CH:6][N:5]=3)[CH:18]=2)[CH:13]=[CH:14][CH:15]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 1364694-(Trifluoromethyl)piperidineHCID 22135502N-(6-chloro-4-pyrimidinyl)-7-Quinolinamine

생성물 1

HCID 22135547Quinolin-7-yl-[6-(4-trifluoromethyl-piperidin-1-yl)-pyrimidin-4-yl]-amine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

This compound could be prepared from (6-chloro-pyrimidin-4-yl)-quinolin-7-yl-amine and 4-trifluoromethyl-piperidine in the presence of K2CO3 and DMF.

출처 및 근거

ORD 기록
ord-2d3e56b5c2074196a1297a47eb3aef6d
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07053088B2

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