1,1'-Carbonyldiimidazole → HCID 22136221, compound

Participants

Reaction Steps

The product of example 2b above, 2-phenoxy-6-aminobenzyl amine, (0.22 g 1.03 mol) was dissolved in dry tetrahydrofuran (8 mL) and stirred under argon at room temperature. 1,1′-Carbonyldiimidazole (0.2 g, 1.24 mmol) dissolved in dry tetrahydrofuran (2 mL) was added and the mixture stirred at room temperature. The solvent was evaporated in vacuo, to give the crude product which was flash chromatographed on silica gel eluted wit 0–10% methanol in methylene chloride to give the title compound as a white amorphous solid. mp 278–280° C.

Provenance & Evidence