Pyridine → HCID 22136390, compound

HRID 1826878Notes

Reaction equation

HRID 1826878 reaction equation
Cl.[N:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12](Cl)=[O:13])=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.[C:15]12([NH2:25])[CH2:24][CH:19]3[CH2:20][CH:21]([CH2:23][CH:17]([CH2:18]3)[CH2:16]1)[CH2:22]2.N1C=CC=CC=1>O>[C:15]12([NH:25][C:12]([C:8]3[CH:7]=[C:6]4[C:11](=[CH:10][CH:9]=3)[N:2]=[CH:3][CH:4]=[CH:5]4)=[O:13])[CH2:22][CH:21]3[CH2:20][CH:19]([CH2:18][CH:17]([CH2:23]3)[CH2:16]1)[CH2:24]2

Participants

5

Reactant 3

HCID 1049PyridineHCID 2130AmantadineHCID 22136358Quinoline-6-carbonyl chloride--hydrogen chloride (1/1)

Product 1

HCID 22136390HCID 22136390, compoundYield 11%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared from 6-quinolinecarbonyl chloride hydrochloride (1.51 g, 10 mmol), 1-adamantanamine (1.73 g, 10 mmol), pyridine (5 mL), and water (200 mL) yielding 330 mg (11%) of (42):

Sources & evidence

ORD record
ord-0786e6b978ba4b099b5ce0fffb6908e2
Source dataset
uspto-grants-2006_05
Patent number
US07053104B2

Reaction notes

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