Pyridine → HCID 22136380, compound

HRID 1826880Notes

Reaction equation

HRID 1826880 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][C:2]=1[C:11](Cl)=[O:12].[Cl:14][CH:15]1[CH:20]2[CH:18]3[CH:19]2[CH2:21][CH:16]1[CH:17]3[NH2:22].N1C=CC=CC=1>O>[Cl:14][CH:15]1[CH:20]2[CH:18]3[CH:19]2[CH2:21][CH:16]1[CH:17]3[NH:22][C:11]([C:2]1[CH:3]=[N:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:1]=1)=[O:12]

Participants

5

Reactant 3

HCID 1049PyridineHCID 2734681Quinoxaline-2-carbonyl chlorideHCID 4394162HCID 4394162, compound

Product 1

HCID 22136380HCID 22136380, compoundYield 37.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared from 2-quinoxaloyl chloride (193 mg, 1.0 mmol), 5-chlorotricyclo[2.2.1.0(2,6)]hept-3-ylamine (129 mg, 0.90 mmol), pyridine (5 mL), and water (50 mL) yielding 100 mg (37%) of (167):

Sources & evidence

ORD record
ord-1e305b7e1f524e59a0c790280986cdcf
Source dataset
uspto-grants-2006_05
Patent number
US07053104B2

Reaction notes

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