Pyridine → HCID 9457045, compound

HRID 1826882Notes

Reaction equation

HRID 1826882 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][C:2]=1[C:11](Cl)=[O:12].[C:14]1([C@@H:20]([CH3:23])[CH2:21][NH2:22])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.N1C=CC=CC=1>O>[C:14]1([C@@H:20]([CH3:23])[CH2:21][NH:22][C:11]([C:2]2[CH:3]=[N:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=2)=[O:12])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 1547949(R)-(+)-beta-MethylphenethylamineHCID 2734681Quinoxaline-2-carbonyl chloride

Product 1

HCID 9457045HCID 9457045, compoundYield 76.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared from 2-quinoxaloyl chloride (0.47 g, 2.4 mmol), (R)-2-phenyl-1-propylamine (0.30 g, 2.2 mmol), pyridine (5 mL), and water (50 mL) yielding 0.49 g (76%) of (172):

Sources & evidence

ORD record
ord-f5e3f4879c8c419b8fe51dcf302b9e1a
Source dataset
uspto-grants-2006_05
Patent number
US07053104B2

Reaction notes

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