Pyridine → HCID 22136376, compound

HRID 1826887Notes

Reaction equation

HRID 1826887 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][C:2]=1[C:11](Cl)=[O:12].[NH2:14][CH:15]1[CH2:19][CH2:18][C:17]2([CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH2:16]1.N1C=CC=CC=1>O>[CH2:16]1[C:17]2([CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH2:18][CH2:19][CH:15]1[NH:14][C:11]([C:2]1[CH:3]=[N:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:1]=1)=[O:12]

Participants

5

Reactant 3

HCID 1049PyridineHCID 2734681Quinoxaline-2-carbonyl chlorideHCID 21483265HCID 21483265, compound

Product 1

HCID 22136376HCID 22136376, compoundYield 84.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared from 2-quinoxaloyl chloride (193 mg, 1.0 mmol), 2-aminospiro(4.5)decane (150 mg, 0.79 mmol), pyridine (5 mL), and water (100 mL) yielding 206 mg (74%) of (236): rt=10.94 min.;

Sources & evidence

ORD record
ord-1d56e2aa29c94b66b50da2b5eb704b0b
Source dataset
uspto-grants-2006_05
Patent number
US07053104B2

Reaction notes

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