HCID 12696803, compound → Clortermine

HRID 1826893Notes

Reaction equation

HRID 1826893 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([CH3:14])([N+:11]([O-])=O)[CH3:10]>[Ni].C(O)C>[CH3:14][C:9]([NH2:11])([CH3:10])[CH2:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:1]

Participants

4

Reactant 1

HCID 12696803HCID 12696803, compound

Product 1

HCID 25223Clortermine

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A mixture of Raney nickel (50% by weight in water; 2.3 g) and 1-(2-chlorophenyl)-2-methyl-2-nitropropane (2.35 g, 11 mmol) in ethanol (35 mL) was shaken under hydrogen gas (60 psig) for 3.5 h. The reaction mixture was then filtered, and the filtrate was rotary evaporated. This provided 2.3 g (110%) of α,α-dimethyl-2-chlorophenethylamine.

Workup

  1. filtrationThe reaction mixture was then filtered

Sources & evidence

ORD record
ord-7475e878476a49b592ca8f2e4046b09d
Source dataset
uspto-grants-2006_05
Patent number
US07053104B2

Reaction notes

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