2-Phenylpropylamine → N-(2-phenylpropyl)quinoxaline-2-carboxamide

HRID 1826894Notes

Reaction equation

HRID 1826894 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][C:2]=1[C:11](Cl)=[O:12].[CH3:14][CH:15]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:16][NH2:17]>N1C=CC=CC=1>[CH3:14][CH:15]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:16][NH:17][C:11]([C:2]1[CH:3]=[N:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:1]=1)=[O:12]

Participants

4

Reactant 2

HCID 113982-PhenylpropylamineHCID 2734681Quinoxaline-2-carbonyl chloride

Product 1

HCID 22136331N-(2-phenylpropyl)quinoxaline-2-carboxamideYield 69.5%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Prepared from 2-quinoxaloyl chloride (193 mg, 0.84 mmol), β-methylphenethylamine (103 mg, 0.76 mmol), and pyridine (2 mL) yielding 154 mg (69%) of (131):

Sources & evidence

ORD record
ord-4840eef1b1fe42de9768156f0e5d424f
Source dataset
uspto-grants-2006_05
Patent number
US07053104B2

Reaction notes

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