HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-dimethyl-1H-indole-2-carbaldehyde → 1-Ethyl-5-fluoro-3-(methylaminomethyl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-dimethyl-1H-indole-2-carbaldehyde | HCID 2771468 | — |
| Reactant | 1-ethyl-5-fluoro-1H-indole-3-carbaldehyde | HCID 22138998 | — |
| Reactant | Methyl 2-((5-bromopyridin-2-yl)amino)acetate | HCID 22139049 | — |
| Product | 1-Ethyl-5-fluoro-3-(methylaminomethyl)-1H-indole | HCID 22139096 | 50% |
Reaction Steps
According to the procedure of Preparation 11 (c), except substituting 1-ethyl-5-fluoro-1H-indole-3-carboxaldehyde (0.2 g, 1.9 mmole) for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (0.1 g, 50%) was prepared as a viscous oil: MS (ES) m/e 207 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07741339B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-35d60f116a474294b0751d7c0af71054 |
| Source note | uspto-grants-2010_06 |