HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 178461307, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 178461359 | HCID 178461359 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 178461307 | HCID 178461307 | — |
Reaction Steps
Hydrolysis of ethyl 4-chloro-6,8-difluoroquinoline-3-carboxylate afforded 10.5 g of crude 4-hydroxy-6,8-difluoroquinoline-3-carboxylic acid hydrochloride. The crude acid (2 g,), thionyl chloride, trans-4-methylcyclohexylamine hydrochloride (748 mg, 5 mmol), and triethylamine (0.3 mLs) afforded crude N-(trans-4-methylcyclohexyl)-4-chloro-6,8-difluoroquinoline-3-carboxamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07053104B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-af69076275114a46999eb20483c5d806 |
| Source note | uspto-grants-2006_05 |