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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1826980Generated: November 2, 2026

Malononitrile → HCID 69620633, compound

https://huagongshe.com/reaction/1826980

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMalononitrileHCID 8010—
Reactant1H-indol-4-olHCID 75421—
Reactant6-Methylpyrazine-2-carbaldehydeHCID 22136797—
ProductHCID 69620633HCID 6962063322%

Reaction Steps

The title compound was prepared from 6-methyl-pyrazine-2-carbaldehyde, malononitrile and 4-hydroxyindole by a procedure similar to Example 57 in 22% yield. 1-NMR (DMSO-d6): 11.30 (brs, 1H), 8.44 (dd, J=15.6, 1.10 Hz, 2H), 7.36 (dd, J=3.03, 0.83 Hz, 1H), 7.09 (d, J=8.51 Hz, 1H), 7.00 (s, 2H), 6.69 (d, J=8.24 Hz, 1H), 6.45 (m, J=3.03, 1.10, 0.83 Hz, 1H), 4.97 (s, 1H), 2.44 (s, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07053117B2
Source datasetuspto-grants-2006_05
ORD IDord-bf9a7be609e340a8939b5496ce1c5ec3
Source noteuspto-grants-2006_05