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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1826983Generated: November 2, 2026

Malononitrile → HCID 69620615, compound

https://huagongshe.com/reaction/1826983

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMalononitrileHCID 8010—
Reactant7-HydroxyindoleHCID 2737651—
Reactant6-Methylpyrazine-2-carbaldehydeHCID 22136797—
ProductHCID 69620615HCID 6962061582%

Reaction Steps

The title compound was prepared from 6-methyl-pyrazine-2-carbaldehyde, malononitrile and 7-hydroxyindole by a procedure similar to Example 57 in 82% yield. 1H-NMR (DMSO-d6): 10.43 (brs, 1H), 8.50 (d, J=1.37 Hz, 1H), 8.38 (d, J=0.82 Hz, 1H), 7.35 (m, J=2.47, 2.20, 1.10, 0.83 Hz, 1H), 7.27 (d, J=8.24 Hz, 1H), 6.72 (dd, J=8.24, 0.55 Hz, 1H), 6.47 (m, J=2.20, 0.55 Hz, 1H), 6.11 (brs, 2H), 5.05 (s, 1H), 2.47 (s, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07053117B2
Source datasetuspto-grants-2006_05
ORD IDord-90d22ea5942a48ea862d82c18259e2d1
Source noteuspto-grants-2006_05