Tert-Butyl nitrite → HCID 10183404, compound

Participants

Reaction Conditions

Reaction Steps

7-Bromo-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-2-imino-2H-chromene: To a suspension of t-butyl-nitrite (34 mg, 0.33 mmol), CuBr2 (68 mg, 0.30 mmol) in anhydrous acetonitrile (1.5 mL) at 0° C. was added 7-amino-3-cyano-2-imino-4-(3-bromo-4,5-dimethoxy-phenyl)-2H-chromene (100 mg, 0.25 mmol). The mixture was stirred at 0° C. for 4 h, then was diluted with EtOAc (50 mL), washed with saturated NaHCO3 (25 mL), brine (10 mL), dried over MgSO4, and evaporated to yield a yellow solid. The crude was purified by column chromatography (silica gel, EtOAc:hexanes, 1:2 to 1:1) to yield 50 mg (43%) of the title compound as a yellow solid. 1H NMR (CDCl3): 7.82 (brs, 1H), 7.38 (m, 1H), 7.30 (dd, J=2.1, 8.7 Hz, 1H), 7.18 (d, J=2.1 Hz, 1H), 7.09 (d, J=9.0 Hz, 1H), 6.93 (m, 1H), 3.96 (s, 3H), 3.92 (s, 3H).

Provenance & Evidence